According to reports in the national media, unknown gunmen attacked the prison in Ehime Mbano district of Imo state.
While the prison was set on fire in the attack, many prisoners escaped.
Yesterday, the prison in Owerri was attacked.
In the attack on the prison in Owerri, the capital of imo state yesterday, 1844 prisoners escaped and 50 vehicles were set on fire.
Such attacks are occasionally carried out by the separatist Biafra Indigenous Peoples (IPOB) in southern Nigeria.
In the operations carried out in the South region on 29 March, 16 IPOB members were captured with guns and bombs.
Millions lost their lives in the civil war that broke out in 1967, when the people of Biafra revolted to demand the establishment of the independent state of Biafra in southern Nigeria.
The Republic of Biafra, which was established in the southeast of the country in 1967, was once again under the sovereignty of Nigeria at the end of the civil war.
The IPOB, declared as a terrorist organization by the Nigerian state, wants to establish an independent state.